I'm open to pretty much any anime/manga so long as it sounds interesting, but I'm a sucker for series with great world building, interesting characters, and unique/spectacular art direction. I won't typically go out of my way to watch yet another generic moe series or crappy light novel-based anime, and I absolutely refuse to read or watch hentai of any kind.
250th Completed Anime - JoJo's Bizarre Adventure: Diamond is Unbreakable
300th Completed Anime - Hunter x Hunter (2011)
350th Completed Anime - Sound! Euphonium 2
400th Completed Anime - Made in Abyss