According to Mainichi Online News, the serial manga Inuyasha will end in the next issue of Weekly Shounen Sunday published on Jun 18. The author Takahashi Rumiko started this series from Nov 1996. 53 volumes of the comic books have been published and the total sales have reached 43 million copies.
Source: Mainichi JP
SUNRISE has started the production of "Inuyasha SP" anime to commemorate the end of the original manga.