Hillary Clinton - Ritsuko Akagi (Evangelion)
Her brand was big in the '90s and is still going strong. Intelligent and highly competent at her job, yet distant in a way that makes her less likable to the public. Relationship status is complicated. Doesn't want you looking at the contents of her computer.
Donald Trump - Dio (Jojo's Bizarre Adventure)
An absurd cartoon. Loves gold. Seemingly impossible to defeat. Certain people of indeterminate irony will claim they "did nothing wrong." (One notable difference: Dio, having built himself up from poverty rather than getting million dollar loans from dad, is actually the more cunning businessman)
Bernie Sanders - Hige Oyaji (Astro Boy, Metropolis, etc.)
A hard-working public servant with radical pro-worker beliefs (whether those workers are human or sentient robots) that find him on the outside of "the establishment." Kind but passionately angry. Looks even older than he is.
Meme-Bernie Sanders - Jesus (Saint Young Men)
If went by the memes of his most passionate supporters, you'd think that Bernie was Jesus, and also that he was going to "make anime real." Therefore, otaku Jesus.
Ted Cruz - Light Yagami (Death Note)
John Kasich - Canada (Hetalia)
Not meant as a commentary on the actual nation of Canada as it exists today (Kasich doesn't seem like Justin Trudeau's type), but rather the stereotype of Canada in Hetalia as continually ignored. Arguably one of the saner characters, but only because talking to bears is relatively less crazy than talking to flying mint bunnies.
JEB! Bush - Naruto
Woobie. Really wants to be hokage/president. Will have to wait out a couple long time skips if that's to happen. Cursed by connection to the demon that destroyed the village/world economy. Inspiration for many an emo AMV.