Tsukune-Chan is a kind-hearted witch who goes around trying to assist people in trouble. To put it nicely, she does not do a very good job of it, and often leaves the situation worse than when she arrived, usually with multiple fatalities. This is played for laughs.
The art style is highly reminiscent of 2x2 Shinobuden, except without the fanservice, so that's a plus. Often, the art would switch into a purposely low-budget appearance to add to the surreality of it. Trading out Rie Kugimiya for Haruko Momoi is a wash. Both have the kind of voice that just makes me want to throttle something. I've
never heard of any of the other seiyuu.
As for the comedy, well, I had to invent the "Crack is a hell of a drug" tag for this one (and promptly tagged six other shows with it). It's nuts. Half of the jokes have nothing to do with anything, and the other half of the jokes are gallows humor. Women are stalked. People are implied to be pedophiles. People are killed by grenades, getting sniped, explosive sneezes, falling off buildings, drowning in oil, other massive explosions, and getting eaten by sharks and dinosaurs. All played for laughs. I appreciated it. The author had to be on crack cocaine when he/she was coming up with this thing.
The Christmas story was by far the most awesome part of the show. Words cannot express how preposterous it was.
All in all, I'm sure I would have found it funnier if I wasn't in such a poor mood to begin with, but a grade just under a 7 will suffice. Can I recommend this to people? If you like absurdist humor (if you liked Bobobo for example) and can put up with the voice of Anise Tatlin, then sure. If you prefer shows like Kanon, then you should probably stay away.