Lot of the longest series are for boys, so here I listed the longest series that are more girls focused as for some reason they are not as well known as the longest boys focused series.
List of series for girls and shoujo anime with highest amount of episodes and total runtime
https://myanimelist.net/stacks/26291
https://myanimelist.net/stacks/32408
TV, 1990,
142 eps
Me:-
Author:10
1588+ episodes
39621 minutes
TV, 2017,
52 eps
Me:-
Author:9
1779 episodes
39276 minutes
TV, 2004,
49 eps
Me:-
Author:10
1082+ episodes
27483 minutes
TV, -,
180 eps
Me:-
Author:9
980 episodes
24500 minutes
TV, 2011,
51 eps
Me:-
Author:10
714 episodes
16672 minutes
TV, 2012,
178 eps
Me:-
Author:10
448 episodes
10926 minutes
TV, 2009,
52 eps
Me:-
Author:10
358 episodes
8599 minutes
TV, 2000,
296 eps
Me:-
Author:9
394 episodes
8371 minutes
TV, 2009,
143 eps
Me:-
Author:9
344 episodes
7862 minutes
TV, 2011,
36 eps
Me:-
Author:10
322 episodes
7028 minutes
TV, 1992,
46 eps
Me:-
Author:10
260 episodes
7002 minutes
TV, 1999,
51 eps
Me:-
Author:10
253 episodes
5422 minutes
TV, 1966,
109 eps
Me:-
Author:10
201 episodes
5017 minutes
TV, 1969,
94 eps
Me:-
Author:10
211 episodes
5011 minutes
TV, 1993,
26 eps
Me:-
Author:10
311 episodes
4953 minutes
TV, 2015,
139 eps
Me:-
Author:10
215 episodes
4828 minutes
TV, 2005,
52 eps
Me:-
Author:10
233 episodes
4589 minutes
TV, 2002,
172 eps
Me:-
Author:9
172 episodes
4128 minutes
TV, 2006,
153 eps
Me:-
Author:10
153 episodes
3672 minutes
TV, 1982,
63 eps
Me:-
Author:10
133 episodes
3237 minutes
TV, 2014,
52 eps
Me:-
Author:10
213 episodes
3075 minutes
TV, 2009,
305 eps
Me:-
Author:10
305 episodes
3050 minutes
TV, 2007,
51 eps
Me:-
Author:10
127 episodes
3048 minutes
TV, 2016,
59 eps
Me:-
Author:10
136 episodes
2952 minutes
TV, 1976,
115 eps
Me:-
Author:10
118 episodes
2950 minutes
TV, 1995,
117 eps
Me:-
Author:10
118 episodes
2898 minutes
TV, 1969,
104 eps
Me:-
Author:10
108 episodes
2840 minutes
TV, 1984,
58 eps
Me:-
Author:10
110 episodes
2640 minutes
TV, 2005,
51 eps
Me:-
Author:10
105 episodes
2519 minutes
TV, 1996,
102 eps
Me:-
Author:10
103 episodes
2472 minutes
TV, 2009,
51 eps
Me:-
Author:10
102 episodes
2448 minutes
TV, 1998,
70 eps
Me:-
Author:10
100+ episodes
2431 minutes
TV, 1997,
100 eps
Me:-
Author:10
100 episodes
2400 minutes
TV, 2020,
48 eps
Me:-
Author:10
98 episodes
2352 minutes
TV, 2006,
225 eps
Me:-
Author:10
225 episodes
2250 minutes
TV, 2001,
26 eps
Me:-
Author:10
90 episodes
2216 minutes
TV, 2003,
52 eps
Me:-
Author:10
91 episodes
2184 minutes
TV, 1984,
23 eps
Me:-
Author:10
112 episodes
2111 minutes
TV, 2008,
13 eps
Me:-
Author:9
89+ episodes
2088 minutes
TV, 2006,
39 eps
Me:-
Author:10
87 episodes
2088 minutes
TV, 1973,
26 eps
Me:-
Author:10
77 episodes
1904 minutes
TV, 2000,
78 eps
Me:-
Author:10
78 episodes
1872 minutes
TV, 2002,
52 eps
Me:-
Author:9
118 episodes
1866 minutes
TV, 1994,
76 eps
Me:-
Author:10
77 episodes
1851 minutes
TV, 1994,
74 eps
Me:-
Author:10
77 episodes
1848 minutes
TV, 1974,
72 eps
Me:-
Author:10
72 episodes
1728 minutes
TV, 1992,
170 eps
Me:-
Author:10
170 episodes
1700 minutes
TV, 1997,
70 eps
Me:-
Author:10
70 episodes
1680 minutes
TV, 1995,
52 eps
Me:-
Author:9
65 episodes
1650 minutes
OVA, 1990,
2 eps
Me:-
Author:10
83 episodes
1612 minutes