Not like other end of the world anime.
First off I tend to not like short 12 to 13 episode anime. They tend to be bad anime with bad stories and un-interesting characters. So I was pleasantly surprised with Saikano.
Saikano is a end off the world anime. Very much different than Evangelion and Rahxephon. Unlike those end off the world who have a broad story and confusing endings Saikano is straight to the point. It doesn't have a broad story with giant mecha, and unknown beings. It concentrates on characters and story. When it comes down to it, it's a tragic love story with meaning. I think it has meaning today. War resolves nothing, and only the leaders are the winners, if we don't stop then endless fighting we'll bring a end to our world.
Saikano is truly great anime that doesn't get enough love a tragic love story that will make you cry almost throughout the entire series. It's also a anime with meaning that everyone needs to see.