Gun Frontier

Both anime's are insanely funny much so i was crying of laughter through out multiple scenes. Both MC's go on an adventure with goals in mine but run into trouble on the way The two anime's have amazing fighting scene's that displays the protagonists abilities Both MC's fight for good reasons and always protect the weak not to mention they are very strong 

Both series have very smart and OP main characters. Both are extremely funny and are better viewed through Dubbed version, with awesome voice actors that make it that much more entertaining. Both have mid western themes with similar art work. Main characters for both series are good nature and would help any helpless person in need. The two series have great Comedy, Adventure, Si-Fi, and action elements. 

Also by iconic anime and manga creator, Leiji Matsumoto. Rich characters and stories with a signature look and feel. Frequent "cross pollination" of characters between series. 

Both series deal with life in an unforgiving Desert. With people who only care about themselves, and where the hero of the story isn't really a hero, but one who is just trying to surivive in an unforgiving enviornment.