The story is pretty good. It's just not presented well in this show. It's about two girls, Lucia and Sumire, who work in a group called Venus Vanguard that exterminates evil spirits called "viruses". Viruses were originally humans, whose souls were snatched away and then became monsters that devour other humans' souls. Viruses only attack humans who can see them. Humans who see them have souls called "fragment". Fragments contain some power which have a specific element of nature (fire, wind, water, earth or lightning). There is one fragment that they called "the fragment", the strongest fragment which has the power to recreate the world and it just so happens that Lucia and Sumire are both halves of that fragment. They are observed behind the scenes by their true enemies that has yet to appear. The overall story is confusing so I think it would be better to just read the manga.
In terms of art, the general design is really good. That includes the characters, their items, and their surroundings. Nice drawing, nice coloring and good basic animation. The problem is that the good comments only reach until the basic animation. Everything else is dull. The action scenes were not at all impressive. A lot of scenes are shown in poor angles. Some scene layouts are bad and some transitions are too fast. The characters have uncool battle movements. And special abilities looks like they're not at all special.
Sounds are the best point of this anime. The OP song is good and likable, the backgrounds are also good and well-suited, the effects are fine and natural, the voices are nice and the ED song is not bad. The sound is arranged very well but it's nothing that people would like or notice so much.
This 12 episode animation of Venus Versus Virus made the characters look bad. The two heroines have a really high coolness potential but the scenes just made them look so-so. Everyone just looked average. No special, admirable feelings for any of the characters at all but Sumire was pretty interesting.
The show is not so enjoyable. It is pretty interesting and there are actually some good scenes at the very later parts, but that's just it. The poor overall presentation just brings the enjoyment down. It ends so bad that the viewers would naturally get angry.
