I had no knowledge about all the Cyberpunk universe when watching the anime. The viewer is put in front of ethical questions like "Is this future for humanity suitable ?", "Would I indulge in such behaviors if I lived in this environment ?" Beware, though, this anime is very violent, depicting a world with high criminality.
Another question asked to the viewer during the show: "Are you as special as you think you are ?" everyone has their own limitations and it's normal. We witness someone who is ready to sacrifice all he has to make his dream true and protect the one he loves. The animation is great, especially during fights and some scenery well accompanied with great OSTs.
There is a romance development very cute to watch which will lead to some tragic events.
I was a bit disappointed at the end which I think was designed to be emotional. They could have played a bit more on the romance shown during the show.
Good anime overall. It will teach you more than you could think and most probably make you feel emotional. Go for it !