If I were to summarize Sousou no Frieren in a single word, I'd borrow a word right from its own chapters, which perfectly encapsulates what it is all about.
That word is "Ephermal."
The hero's party's epic adventure, in the grand scheme of thing, was ephermal. It might have took years to defeat the demon king, but from Frieren's eyes, an elf that can and have lived for centuries, it felt like a few days.
Learning magic, was ephermal.
Travelling around the world, was ephermal.
Staying in a certain place for weeks, even years, was ephermal.
When you have lived for centuries, everything blends together.
Defeating the demon king is just as memorable as the passing words of a friend.
Frieren's value of time is shown clearly whenever she casually proposes staying in a place for months or years to await bad weather or a certain event.
After all, what is one or two years when your lifespan is in the thousands?
It's only natural to consider most ephermal things insignificant.
And this is Frieren's story of realization that not all that is ephermal is necessarily insignificant.
It's only 80 years after the passing of her former party members -which also marks the beginning of the story- that she begins to realize that those days were worth more than she had initially valued.
This is a story of regret and melancholy, laced with coming to terms with the past and moving on.
It's the story of "what could have beens", but thanks to her new companions, it is also a new beginning filled with "what will bes."
Relating to an Elf's sense of time might seem impossible, if it wasn't for the extremely atmospheric dialogue, perfectly placed flashbacks, and gentle eye-pleasing, yet horrifyingly expressive art. Just a single look at Frieren's smile in a panel following a flashback is enough to convey her regret.
You will feel the same sense of regret Frieren feels, if not more.
You will come to learn to enjoy the little things, just as Frieren has.
You will realize that your time maybe limited, but your legacy could be eternal, just like how Himmel is still admired and respected, as observed by Frieren everywhere she goes.
And most importantly, you will learn to act before it is too late, unlike Frieren.
This is a modern classic in the making.
This isn't memorable because of flashy fights, or pretentious dialogues that you will end up forgetting in 5 years tops, only to be replaced by the new hot thing.
This is memorable because of how impactful and relatable it is, and is something that will stick with you to the very end.