Some minor spoilers might be present in the following review:
Fullmetal Alchemist Brotherhood is awesome!!! I loved the 2003 FMA, but as this one follows the manga more accurately, there are lots more moments that I enjoyed (e.g. EdxWin moments)...
The art is beautiful (as usual, Bones did a GREAT job)...however...I prefer some facial/expression details in the 2003 series more...
As for the music and sound effects...personally I am still overwhelmed by the gorgeous pieces from the 2003 FMA...so I would say they are decent in this one ;)
The storyline is genius and the meanings it brings about are deep- Arakawa is one of the best mangaka =) and there are not plot holes whatsoever!
You'll enjoy it!!