The original story (titled Osomatsu-kun) is similar to this reboot, but more simplified and more family-oriented. Here, it's set where our main characters (a set of sextuplets) are grown-up and doing adult things. If you ignore what it originally was about and not think of this as a new adaptation, it still works in its own way. There isn't any overarching story to it, as most episodes have smaller segments within. However, as the series progresses, there are references of things from past episodes. Think of this kind of like a sketch comedy, but also with some real emotional moments.
I believe the characters are what make the show so great. I tried to get a look into the earlier iterations of the series (manga, various anime), and while I didn't find too much (difficult to find) what I did find was interesting. The sextuplets in their original state, all looked identical (obviously), but their personalities were almost the same. With this new show, all six have their own individual personalities, and are even distinguishable (though it took me a few episodes to fully do so). The side characters, who are regulars of the original series, are also pretty entertaining. While having some characteristics that are new to the reboot, there are still those that what make them their character (physical appearance, speech quirks, catchphrases, etc.).
The animation is quite pretty to look at, and it's what initially caught my eye when hearing of this show. It's very colorful and compliments the outrageous things that happen.
Before deciding to watch this series, I was skeptical having not read the manga or seen previous anime adaptations. However, upon watching (which I am glad I did), I concluded that you don't necessarily have to be familiar with the older material, as it's easy to figure out the elements that made the original (character quirks and the like). As a comedy, it's great. There is never a dull moment (save for the few cases of drama), and I always looked forward to seeing each episode.
