The Melancholy of Haruhi Suzumiya is a great comedy with excellent characters. Its an interesting blend of sci-fi, action, romance, and comedy which makes a surprisingly entertaining animation with great originality.
The whole series is a little confusing and might be a bit mind-boggling to some if they watch the episodes in order from #1 - 14. But here is the trick to keeping your head from exploding and making the show more understandable: (if you prefer sense over insanity) watch the episodes in this order #2, 3, 5, 10, 13, 14, 4, 7, 6, 8, 1, 12, 11, 9 - this will make the anime chronological in events, time, and character appearance. Episode 1 and 12 are my favorites but everything before and after are just as wonderful.