Needless to say, this is the best anime that ever been created so far,
so I'm just going to point out a few things that I think makes it sit on the throne.
-Story : Exceptional, if you find a better story on this genre, please tell me, because I am dying to watch a better anime than this one.
-Alchemy : The characters fight using alchemy, which is science-fiction like. It makes you believe something like that could really be possible one day.
-Brotherhood : The bond between the two brothers is really strong. I realized this only after I watch the show for the second time.
-Wide range of audience : I believe the show has a wide range of audience, I am sure it can be easily enjoyed by people from age 12-30.
Last but not least, if you are someone who study or at least interested in philosophy, I am sure you will find this anime very, VERY interesting.
That's all, I hope this review helps.
Sorry for my bad english.