This is a harem anime about a mangaka of an ecchi manga and the girls around him. His three assistants (though two are hardly ever seen actually helping his manga at all), his editor, and several other minor characters. The main character, Aito, is absolutely ridiculous. His emotions seem bipolar and he can quickly flip from being a perverted idiot to a sympathetic and kind mentor in the blink of an eye. His voice during many of the perverted scenes gets so high it's annoying (though I will give credit to his voice actor for having excellent vocal range) yet at other times he can be quite likable. He has balls of steel and, unlike many male protagonists in ecchi anime, has almost no fear of asking to see a girl's underwear or to touch them (in fact he even succeeds a couple times).
As for the girls, they are mostly archetypal, though they do break out of their archetypes and become unique on several occasions. Aito's main assistant, Ashisu, is the girl who least fits into any archetype. She is Aito's main love interest (of course she would rather die than feel the same way about him). Being an assistant, she has dreams of debuting and becoming a real mangaka. She has a love-hate relationship with Aito which can range from her going along with his perverted schemes to acting like a dominating yandere around him. Mihari is Aito's editor and friend from high school who has long had a crush on him. Aito has no clue of course because Mihari is your typical, lovable tsundere. Rinna, a well-endowed airhead, and Sena, a spoiled-rotten weakling, are much less important and only have a few important scenes despite being main characters.
The animation is fairly well done for an ecchi anime. Despite all of it's focus on panties, the amount of ecchi content is probably not as much as you're expecting. There are more moments with sexual innuendos and Aito asking to see panties than there are actual moments of near-nudity. The character designs are average and since most of the anime takes place inside of Aito's apartment studio, the characters are usually seen close up and tend to avoid being shown with minimal detail when far away from the viewer like many shows do to save some of the animation budget. Still, this means there are not too many scenery changes, though there are still a beach/hot spring episode and several trips to lingerie stores in the mall. As for the sound, the music is typical an for ecchi and comedy anime. Most of the time it is light-hearted, but it can get intense to match Aito's bizarre outbreaks. Still, it does nothing more than fit the mood fairly well at the time and is often unnoticeable.
"Mangaka-san to Assistant-san to" is a fairly entertaining, simple, and short (12 minute long episodes) ecchi comedy. If that's all your looking for, then you've found something you'll enjoy. If you're looking for one of the best ecchi shows out there, or something with tons of nudity, then you'll probably be disappointed. The show does get a little better as it goes and as you grow somewhat attached to the characters (I personally enjoyed Mihari with her crush on Aito the most and I was happy that there was an entire episode dedicated to that). Also, if you're going into this expecting a lot of focus on making manga, you would be better to check out something like Bakuman as this only occasionally focuses on how tiring the process can really be.
