Samurai Deeper Kyo is based of the still running manga series by the same name.
In the year 1600, during the battle of Sekigahara, warriors Kyoshiro Mibu and "Demon Eyes" Kyo - the legendary slayer of a thousand men - engaged in fierce combat. Both men disappeared when a meteor crashed in the battlegrounds. Four years later, Kyoshiro is spotted on a rural highway, acting as a traveling medicine salesman. He is captured by the female bounty hunter Yuya Shiina when she discovers that deep inside him is the dormant personality of "Demon Eyes" Kyo himself.
Now on to all the problems I had with the show. First there's the story stated above, which is just a jumble together of stories from the manga. Then there's the so called animation done by Studio Deen. Were they trying to make a crappy American cartoon, I don't get it. The music was also terrible it didn't add anything to the show. Finally the characters which had one or two moments of enjoyment, but overall were terrible. One more thing don't watch this show in the dub version, you'll hate it even more.
Overall was this a terrible anime series...no, but it pales in comparison to the manga series.