 If you liked
NHK ni Youkoso!
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 ...then you might like
Aura: Maryuuin Kouga Saigo no Tatakai
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If you're looking for anime that deal with characters and their social problems in a realistic and serious manner, then look no further. The theme of escapism permeates these works, and the characters struggle with the world and people around them. Perhaps you may even relate to some of the problems they face. Whether that is the case or not, there is still a sublime message lying in both of these great titles.