Keep in mind this is a review, not a summary! If you want a summary go to wikipedia.
Story: The story in this show is actually somewhat unique. Dealing mainly with a rather funny (closet) lesbian lead character, Kanako, who has problems with guys (she actually contracts hives if she comes in contact with them) and another lead character, Mariya, who is actually a male cross dresser but looks rather feminine. The actual plot jumps around from episode to episode but has so far remained genuinely entertaining and by episode 6, the larger plot of the show all together is revealed to you.
Art: The animation in
the show is superb, I have only found one scene in the first 6 episodes that the animation (a characters face) looked just a tiny bit awkward. Maria†Holic has a great opening and the actual show all together has a very unique style to it as well, featuring vivid colors, interesting cut-scenes and slightly unorthodox backgrounds. (I mean that in a good way)
Sound: The voice acting is great, the actors voices fit the characters and sync well. Just what one would expect from any quality anime. The music does a nice job of supporting the story throughout the show and I think it fits very well with the overall "feel" of the show.
Character: The characters are pretty interesting, the lead, Kanako, is damn funny at times while the other lead Mariya with her cruel, shameless humor keeps it interesting as well. They haven't really expanded much on any side characters as of yet, but none stand out to me to be particularly boring. (yet)
Enjoyment: I haven't enjoyed a show this much for a while. Like I said before its quite unique and with some pretty funny moments. The last episode I watched, I must have laughed out loud at least 5 times. The same could be said for the other episodes I've seen.
Overall: While its not the best show I've ever watched, it certainly was one of the funnier shows I've watched. Bottom line: If you like humor in your anime, try to sit down and watch this show, even if your uncertain about the whole lesbian and cross dresser thing, I can bet you will enjoy watching Maria†Holic. So stop reading this and go watch it! :P