The female protagonists are very similar and both main protagonist's love interest are their counterpart's friend or acquaintance. Basically the premise is very similar except where in Omae the male protagonist is an otaku, in Toradora the main protagonist is just a delinquent-looking individual.
Both these series have romance elements and an interesting story so far. They also both center around popularity and other people's impressions of the main character. The main characters are very self conscious.
One similarity between these two titles is that a female character becomes interested in a male character who happens to be otaku. Provided that she likes the aforementioned male character so much, she ends up investing herself in various otaku activities.
Both stories feature a main character who is a closet otaku. Said characters actively try to keep this fact about themselves secret, while dealing with the fact that at least two people close to them know, or will discover this closely guarded secret. Both are also school life stories that have romantic subplots.