MISAKA 10046 is one of the original production of Misaka Sisters originally used for the level 6 project, which was to be killed in combat by Accelerator for him to achieve level 6. But the experiments were canceled when Accelerator was defeated by Touma.
MISAKA 10046 visited Accelerator in the hospital and gave him Estelle's message. She acknowledged and showed gratitude for Accelerator turning a new leaf and protecting the sisters, as well as showing concern for his well being, bearing no grudge towards him. When he claimed that he didn't do what he did to save them that time, she smiled as seeing through his cold facade, just like Last Order does. They had a rather friendly interaction. It's not certain, but it is possible that unlike the other standard Sisters, she may prefer Accelerator over Touma. Accelerator later saved her after she had got abducted which she is also rather grateful of.
