The Azumanga manga is almost flawless. I can't think of anything to complain about or point out as a flaw. The only thing that might be an issue is that some (as in very few, maybe 2-3) text-boxes are too crammed with text, making the text small and hard to read. But if you get the Azumanga Daioh Omnibus, which contains all four Azumanga mangas in one set, you won't have an issue because the omnibus is huge and "blown-up," so that even tiny text is easy to read. And for that matter, art-work that features a lot of detail in a small area is now vibrant and beautiful, and the characters look shaper than Osaka's wit.
If you have a choice between the smaller, individual mangas or the omnibus, I recommend the bigger, complete omnibus. Unless you don't want to lug around the rather large tome, and prefer a small compact single manga.
I have only read the ADV Manga translations of the Azumanga Daioh manga in the Omnibus version. I very much want to read other translations someday soon, such as the Yen Press version of the Omnibus, which is an improved version of the ADV Manga Omnibus. The Yen Press Azumanga Daioh Omnibus features an entirely new translation, full-color pictures of the Azu-Crew in between each chapter, (this not only serves as some neat art-work to look at, but a very clear message that a new chapter is beginning) and brand-new, never before read content that expands on the lifes of the girls and their accomplices.
In any form or translation, Azumanga Daioh is a juggernaught title of the anime world, and if you haven't read it yet, you're a bonkler.
SATA-ANDAGI!
