It's a gag reel anime, really, so there's not much that can be said. Tackling on the more technical aspects first? I'd say the artstyle is vibrant and the animation fluid, surprisingly so sometimes so it definitely meets expectations in those regards, but considering there is no story, the characters are one-note, the shorts often make no sense, if at all, and that it's aimed at an audience of kids no older than 12 at best? I'd say this one misses the mark for adult viewers unless one is looking for a cheap, noncommital laugh or two by avoiding better comedies out there.
Regarding the characters, they're all middle schoolers who really wish they weren't there but carry with themselves their own unique attributes. One, for example, is a character which is initially introduced as a 'rival' to the main characters but ends up being an actually nice-hearted kid who is always willing to help despite his fearsome (for a kid, at least) appearance which would suggest otherwise. They're not exactly complex and not entirely one-note? But once a character has been assigned an episodic gag, they will live and die by that gag which can get tiring really fast.
The only thing keeping me from dropping this show is my absurd and stubborn dedication to finish an anime once I've started it. Sometimes I chuckled and at other times I was bored, but the one thing I can say with confidence is that 100% Pascal-sensei is, at the very least, a show most kids who don't care about joke layers or context will enjoy so, if that's your cup of tea, then by all means go for it.