I think it's worth noting that this show was probably never meant to click with western audiences, Super Milk-chan is a show that prides itself on referencing as much 60s-70s anime, manga and general Japanese pop culture from that time period in its twenty-four minute running time as possible, but I'm pretty sure that most of it's audience in Japan didn't get it either as it's a show that's nonsensical to a T (or an N, in this case...).
To explain this show would take forever, to explain why this show is one of my favourites? Even longer than that. While I myself have no idea what is going on as I have barely any knowledge on Japanese pop culture, I think that this show has a unique, quirky charm to it that is why it fits so well in Adult Swim's own absurdity. Everything about this show is confusing and by the end of any episode you decide to re-watch, you will have barely any clue as to the first viewing. The character's conflicts, their notions as to why they do what they decide to do and why they do it is also shrouded in absurdity, confusion and genuine disbelief.
One of the series' strong points is it's art, which I doubt this series would have it's cult following if it weren't for it. It's an art style reminiscent of a Japanese character franchise and is stylized in such a way that mirrors the show's bizarre nature. The character designs are fresh and unique and the world they live in is as pleasant on the eyes. Aesthetically pleasing? Definitely. Does this ease the show's weirdness? No. Not at all.
I may be hamming this up just a little, but note that what makes this show so mediocre, so terribly incomprehensible is what I think is what makes it watchable. Yes, it's bad, but it's those aspects of its badness which turns it into something actually fun to watch.
Super Milk is a show which earns it's title among stoners as, "No, dude, you need to watch this absolutely baked to the bone and THEN it'll be funny." Because for everything this show is - pop-culture-reference-rammed, viewer-alienating-absurd and confusion-chock-full-crammed, it's still entertaining, and it's fans will tell you that you don't need to know what's going on to have a good time.
Watch it because it's weird and confusing - because making sense of this little enigma of a show will just melt your brain into milk.