First of all, Killy. He talks five times through out the whole movie, and when he does he sounds like an uninspired robot. With his behavior so illogical and stupid, there should be some kind of explanation to why the young girl gets attached to him (like, was she raised by cold, feelingless robots herself and have some kind of parent issue? No! She's the daughter of the leader, just like Nausicaa!). The "goth hero with a secret"-image that was cool in the manga turns into some kind of over powered harem manga MC, intentionally made with no personality so one can focus on the girls.
Second, the rest of the cast. The first 15 minutes I was in total denial, like, "Oh, they'll die soon so Killy gets a good appearance", I just couldn't believe they'd puttogether the most unexciting, generic and boring characters imaginable. The person responsible probably did this on the subway on the way to work on the first day of production. Character 1: cute girl, big boobs, forward and heroic personality, but still moe, big boobs, blushes when she shows her face the first time since she's a tad tsundere. Character two: clumsy, moe, big boobs. Male characters: just like that kid in Claymore. See?! If they got the Automated Factory (or whatever the name was) to think up such generic characters they'd think it was malfunctioning. Lame!
Third - no monsters. SERIOUSLY!!! No mutants, no goth master monster robot whatever, no tubes and sharp teeth and floating things and shit. Like, the monsters were the coolest in Blame and Bio Mega, and here, they were all lame robots who walked just like that one funny titan in Attack on Titan, with no personalities and quirks, just boring robots.
The story is just as generic as the characters. The person who wrote it probably haven't even read the manga, instead just looked up a few Amazon reviews and took it from there. Hero, robots, boobs, explosions, bang bang, boobs, a tribe of starving people, how hard can it be? Very hard obviously, even if they didn't call it Blame! this would still suck.
So the art is cool, and compared to earlier attempts the animation worked pretty well, the bodies didn't move just as puppet like as they used to. The only thing really good is the incredible scenery which they really did justice to Tsutomu Nihei's original art, and I guess it's worth seeing it just because of it, but then again you can read the manga and actually get something out of it more than pretty industrialized landscape.
Soooo, seriously. This was a huge disappointment. I'm going to read the manga again, and forget this ever happened.
