Azumanga Daioh was one of the first comedy anime series i watched, and i must admit, i enjoyed it immensely. Right from the very first episode. i felt that this was going to a good one. The comedic timing is fantastic, the story is solid, with all characters being involved and developed, without it feeling like a chore. The characters in this series are amoung the funniest i have come across in anime. They come across as very real but still special.
If you are on the fence about watching this anime, i would wholeheartedly recommend it. You'l be glad you watched it.