The most important feature of No. 6 is the element of surprise. Most of the events that will happen won't be expected and those that one expect will most likely not happen!
It is not an all happy go lucky anime despite the fact that it's more colourfull than less dark or cruel anime(like darker than black or steins; gate).
It really works on its characters and their feelings and backgrounds, so if you are not prepared to think a bit more deep about feelings and getting in the shoes of someone then don't watch it!
Although it is a rather sensitive anime if you don't like shocking events like death-and even massive one- then don't watch it!
I personally saw a video and like Nezumi that is why I started the anime!