 If you liked
Ookami to Koushinryou
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 ...then you might like
Magdala de Nemure
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Made by the same author, both series adapts a fantasy story with a rather unique premise. The main male protagonist from both series are clever with an intellectual mind. Their involvement with a haughty female protagonist connects them together in a story filled with logic. In Magdala de Nemure, the series deals with alchemy (science) while Ookami to Koushinryou (Spice & Wolf) revolves around economics (finance and business). We also get to see the relationship connection between the two main characters as they learn more about one another. Both series also adapts fantasy themes with an unique presence of its world fiction.
Both series are by the same author and share the same basic style. Magdala focuses more on alchemy than economics but again looks at it from a real world perspective and presents it based on logic rather than magic. Like Spice and Wolf, Magdala also features an animal eared female love interest who banters back and forth with the MC in much the same way. Again the two face difficulties from superstitious authorities and have to outsmart their opponents to stay alive