 If you liked
Tantei Gakuen Q
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 ...then you might like
Kamisama no Memochou
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Mystery is the theme in both of these series so for you fans of detective fiction out there, these two anime(s) are definitely something worth checking out.
Many of the cases have plot twists that tests the protagonists to various points.
And of course, there is drama, comedy, and small hints of affection (not necessary romance although it may be interpreted that way).