 If you liked
Sayonara Zetsubou Sensei
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 ...then you might like
3-gatsu no Lion
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Depression? Well, both of these anime have it. But they access it very differently.
Sayonara uses depression as kind of a comedy element, while 3-gatsu uses depression as a story element to make series more deep.
Both are made my Shaft studio so you can expect similarities in many ways!