Anko Uehara is an athletic girl with well-off parents who has her own trio, in which she is accompanied by Naoko Asano and Mayuko Izumi.
Anko is one of the first of the class to start trouble for Eikichi Onizuka, due to her and her friends' constant mistreatment of Noboru Yoshikawa. After the most recent assault on Noboru Yoshikawa leaving him severely beaten and humiliated yet again do they get taught a lesson by Onizuka, who literally spanks them at a karaoke bar and takes pictures of himself committing the act. Afterwards, Anko gets her mother, the president of the local Parent-Teacher Association, who believes her daughter is incapable of wrongdoing, to get Onizuka fired. This backfires, with the help of Noboru and Yoshito Kikuchi, who reveal her cruel, bullying nature in front of the student body and PTA. Anko tearfully confronts her mother about their relationship and perfectionist expectations of her, which leads to some family reconciliation and doesn't get any serious retribution from what she and her friends had done.
She and her friends keep their distance from any other attempts by students to get Onizuka fired, despite giving their verbal support.
While still cold to Onizuka, Anko allies with him, after being fed up with Miyabi Aizawa's manipulation of others for her own gain. When Onizuka is framed for embezzeling funds for the school trip, she offers her credit card for use, but he flat-out refuses.
On the school field trip to Okinawa, her mean streak towards Noboru continues to persist, even escalating, as he and Onizuka start playing pranks of their own against her and her friends. In an ironic twist, Noboru saves her life, after her own prank fails. During a near-death experience, a flashback reveals her bullying stems from growing up with an abusive, older brother, who in turn, was abused by their father.
Shortly after, she develops feelings for him, and unsuccessfully tries to deny them. It takes an Onizuka scheme to get her to admit it.