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The series' most prominent villain, Alphard is an attractive young woman who is both the leader of a terrorist organization called Snake and Canaan's arch-enemy. She appears easily capable of taking down Canaan even though the latter uses her synesthesia, reasoning that she is no longer manipulated by feelings unlike Canaan. She carries a FN Five-seveN USG as a sidearm.
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Top 15 Anime Assassins
These anime assassins tend to be slightly more capable than your average real life assassin...be very scared.