Cheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore

Both MC's run an apothecary in a slow life isekai. Cheat Kusushi is very fluffy with its vibrant pastel colour palette and lighthearted mood whereas Shin no Nakama has a lot more going on in moods but with a heavier plot in turn making it more serious compared to. Shin no Nakama has intense, grueling, and violent scenes as each episode continues on its plot whereas Cheat Kusushi is full on fluff in its more episodic storytelling. There is a little bit of drama in some episodes of Cheat Kusushi and Shin no Nakama does have its share of lighthearted banter as well so there is a bit of balance in both, despite them leaning more in the opposite direction of moods in both. read more 

A pharmacist is reborn in another world.  

Both involve a fantasy world where the main character specializes in potion-making. 

-both are relaxing -both MCs is in another world -both MCs is the center of attention -both anime have a fantasy theme  

both are chill anime about getting away from a toxic life and living peacefully 

Similarities - Both MCs leave the city and try to live a quiet life in the county side (gardener/chemist) - Both MCs are powerless in their current world - Both MCs isekai from modern day Japan/China to fantasy world - Both MCs become center of attention after an event Differences - MC in isekai drugstore is knowledgeable about medicine VS MC in Spirit Seed Manual is knowledgeable about the typical isekai - MC in Spirit Seed Manual gets caught up with powerful beings VS MC in isekai drugstore lives quiet life with the people in his village 

Both are about a medical practitioner in the fantasy world making the world easier to live in with simple medicine. 

Similarities - Both MCs transported into another world/the past - Both MCs use the skills of their past life/modern life to refine medicinal ingredients - Both MCs use recipes to penetrate the new world's economy - Both MCs are generous and don't abuse their knowledge of medicine Differences - Yao Shen Ji pill refining/medicinal ingredients is a small part of the overall story - Yao Shen Ji is a action/adventure/fantasy cultivation chinese donghua - Drug store is a story about a business and the overall story revolves around medicine/health/refining medicinal ingredients - Yao Shen Ji reincarnated into his past life VS Drug Store isekai from modern day Japan into fantasy world 

Both protagonist isekai-ed to a fantasy world, living a slow life and helping people in need.  

The main characters both have a cute wolf friend who is overly clingy and attached, both share the same amount of comedy, light and fluffy almost relaxing iyashikei atmosphere. 

The magic, the world building. I highly reccomend they are quite simular. 

Similarities - Both MCs reincarnated from modern day Japan into a fantasy world - Both MCs want to live a normal, mundane life - Both MCs become center of attention through word of mouth - Both anime use comedy and friendship to drive the narrative Differences - MC in drugstore is a male pharmacist VS MC in average abilities is a female magic student - MC in average abilities has overpowered traits (elder dragon) VS MC in drugstore doesn't have any overpowered traits apart from his medical knowledge