Fullmetal Alchemist

Synopsis

In a flashback that continues through to episode nine, the Elrics learn alchemy from a very young age, taking after their father, who apparently abandoned his family when Al was still too young to remember him. They show their alchemy to both their friend Winry Rockbell and their mother Trisha. Trisha encourages them in the pursuits of alchemic knowledge, but she dies from a sudden illness and the brothers vow to revive her with alchemy. They apprentice themselves to an unnamed alchemist, and after their training, they attempt to resurrect Trisha. The transmutation goes awry, in which Edward loses his left leg and Al loses his entire body. Ed then sacrifices his right arm to attach his brother's soul to a suit of armor. Alphonse carries Edward's broken bleeding body to Rockbell Automail. Roy Mustang arrives unexpectedly, having received a letter the boys sent to his office, inquiring about their father Hohenheim of Light. Having seen the attempted human transmutation, Mustang tries to recruit the boys to become state alchemists, but Winry's grandmother Pinako angrily orders him to leave. Ed pays Pinako for automail limbs and decides to become a state alchemist so that he can gain privileged access to the state library, and find a way to restore Al's body. The Elrics burn down their childhood home so that in efforts of not giving up and try to return and leave Resembool.

(Source: Wikipedia)