 If you liked
Kaze Hikaru
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 ...then you might like
Kusuriya no Hitorigoto
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Both "Kaze Hikaru" and "The Apothecary Diaries" have female protagonists who are small but assertive about their passions (in a comedic way). Mao Mao is very clever in a Sherlock Holmes sort of way and Sei has an instinct that tends to get her into trouble. The dynamics between the girls and their love interests hits a similar comedic vein. Sei is on the serious side and since it's shoujo, pines after the aloof Soji. Mao Mao is seemingly indifferent to Jinshi's advances but they're cute together and help each other out throughout the story. Both series are historicals, one is set in Japan's bakumatsu
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