 If you liked
Trigun
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 ...then you might like
Grenadier: Hohoemi no Senshi
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Well basically, both the main character doesn't want to kill people and each series is funny as hell! And it has the same theme too.
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Recommended by theplayster
Both shows have a single lead character(Trigun = Male, Genadier = Female) who ,while supremely skilled, is not totally invincible. The worlds also are in a similar state with interesting variations such mountain pass where the wind is so strong it keeps dead bodies flying around in a perpetual swirl. Also in both shows interesting and powerful boss characters show up to channelge the hero and their unlikely allies with both placing a small but focused dedication towards comedy. A++
Both feature highly skilled gunmasters as the protagonist. Grenadier is more lighthearted, and follows a different plot, but at their core, both series are very similar.
Both series have a gunslinger who is a pacificst and don't like fighting, and both of the protagonist are blond hair as well, and both the protagonist have almost unparrell gunslinging abilities well, only a slight few differences is there a little more fanservice then Trigun, but still join Rushina Tendo as she travels to find the path of making peace without killing
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Recommended by Anime_Dude7
I think Trigun is way better then Grenadier. But, here's how I find both animes similar to each other. Rushana is the female version of Vash the Stampede and the story is almost the same. But both of them are different in some ways.
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Recommended by Nerdszrule89
Grenadier is more or less "If Vash were a woman..."(or Trigun is "If Rushuna were a man..."). Basically both series are about peaceful protagonists on the journey, who avoid violence, fight only when they must and try not to kill their opponents. Also fights are similar in both series (revolvers, canons, pistols, dudes with robotic armor, main characters' extraordinary bullet evading skills). The main difference between the series is that Grenadier is more light-hearted, while Trigun has a touch of drama. Also Grenadier has an element of ecchi absent in Trigun.