 If you liked
Ookami to Koushinryou
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 ...then you might like
Sakura-sou no Pet na Kanojo
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Although the atmosphere and setting are hardly similar, both series start out with a male protagonist having a strange encounter with an eccentric girl, and having to live with, take care of, and overcome hardships with (or relating to) said girl throughout the anime. The girls in both series are both often called out for their differences by everyone else, and are highly revered for their unique qualities.