Naruto: Shippuuden, Saint Seiya: The Lost Canvas - Meiou Shinwa Recommendations
In both there is a strong bond between the three protagonists of the story. One of these three ends up going to the evil side, causing much pain to the other two.
The value of humans, death, reality, and relationships.
The main protagonists are hyper active, optimistic, strong willed superhuman who continue to mature and grow as the plot moves forward. They both start out as immature and unable to solve any problems on their own.
The main protagonists attempt to save their closest friend from disaster by putting their own morals, life, and dreams on the line. Through chasing their friends, they learn more about themselves, their friend's pain, and mature mentally and physically. Neither of the protagonists will budge in their quest to save the world, save their friend, or save the people that they care