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What is Xanax?
Xanax: instructions for use
Composition
Description
pharmachologic effect
Pharmacokinetics
Indications for use
Contraindications
Pregnancy and lactation
Dosage and administration
Side effect
Overdose
Interaction with other drugs
Application features
Precautionary measures
Release form
Storage conditions
Shelf life
Pharmacy sales terms
Composition
One tablet contains: alprazolam 0.25 mg.

Excipients: microcrystalline cellulose (E460), lactose, starch, sodium dusate + sodium benzoate (E211), colloidal silicon dioxide (E551), magnesium stearate

(E470).

Description
White biconvex elliptical tablets with the inscription "Upjohn 29" on one side and notch on the other side.

Pharmachologic effect
Drugs affecting the CNS, a class of 1,4-benzodiazepines, presumably exert their action by binding to the stereospecific receptors of the central nervous system. Their exact mechanism of action is unknown. From a clinical point of view, all benzodiazepines have a dose-dependent inhibitory effect on the central nervous system, ranging from a mild disruption of test tasks to hypnosis.

Pharmacokinetics Suction

Alprazolam is completely absorbed after ingestion. The maximum concentration in the blood plasma is reached within 1-2 hours after taking the drug. Plasma concentrations of the drug are proportional to the dose taken. In the dose range from 0.5 to 3.0 mg, the maximum concentration of the drug in the blood plasma ranged from 8.0 to 37 ng / ml. Using a special method of quantitative analysis, it was found that the average half-life of alprazolam from blood plasma in healthy adults is about 11.2 hours (range: 6.3 - 26.9 hours).

Please note: Take Xanax with normally dosages: 0.25mg/0.5mg/1mg/2mg. If your doctor write for you 1mg tablets please don't take 2mg dose!
Distribution

Alprazolam binds to plasma proteins in vitro (80%). In most cases, serum albumin is involved in the binding of the drug.

Metabolism / Elimination

  Alprazolam is actively metabolized in the human body (predominantly by cytochrome P450 ZA4 (CYP3A4)) with the formation of two major metabolites in blood plasma: 4-hydroxyalprazolam and a-hydroxyalprazolam. In addition, benzophenone formed from alprazolam is detected in humans. Their half-life is similar to the half-life of alprazolam. Plasma concentrations of 4-hydroxyalprazolam and a-hydroxyalprazolam with respect to the concentration of unchanged alprazolam were always less than 4%. The reported relative activity of 4-hydroxyalprazolam and a-hydroxyalprazolam in experiments on the binding of benzodiazepine receptors and in models of inhibition of induced seizures in animals is 0.20 and 0.66, respectively. Such low values ​​of concentration and even lower values ​​of the activity of 4-hydroxyalprazolam and a-hydroxyalprazolam indicate that the probability that they will significantly enhance the pharmacological effect of alprazolam is very small. Benzophenone is an inactive metabolite.
Alprazolam and its metabolites are mainly excreted in the urine.

Special patient categories

Changes in the absorption, distribution, metabolism and excretion of benzodiazepines were observed in various diseases, including alcoholism, impaired liver and kidney function. In addition, changes were also noted in elderly patients. The average elimination half-life of alprazolam in healthy elderly participants was 16.3 hours (range: 9.0 - 26.9 hours, n = 16) compared with 11.0 hours (range: 6.3 - 15.8 h, n = 16), observed in healthy adult participants. In patients with alcoholic liver disease, the half-life of alprazolam ranged from 5.8 to 65.3 hours (average 19.7 hours, n = 17) compared with 6.3 to 26.9 hours (average 11, 4 hours, n = 17) in healthy participants. In the group of participants suffering from obesity, the half-life of alprazolam varied in the range from 9.9 to 40.4 hours (average 21.8 hours, n = 12) compared with 6.3 - 15.8 hours (in average 10.6 hours, n = 12) in healthy participants.
Due to its similarity with other benzodiazepines, it is believed that alprazolam penetrates the placental barrier and is excreted into human breast milk.

Race - In persons of the Mongoloid race, the maximum concentration and half-life of alprazolam is approximately 15% and 25% higher than those of the Caucasians.
Children's age - The study of the pharmacokinetics of alprazolam in children was not conducted.
Gender - The gender of the patient does not affect the pharmacokinetics of alprazolam.
Smoking - Alprazolam concentrations in smokers can be reduced by up to 50% compared with non-smokers.

Drug interaction

Alprazolam is mainly eliminated by metabolism mediated by cytochrome P450 3A (CYP3A). The majority of drug interactions registered with alprazolam are interactions with drugs that have an inhibitory or stimulating effect on the CYP3A4 isoenzyme.
Compounds that are potent inhibitors of the CYP3A isoenzyme can be expected to increase plasma plasma alprazolam concentrations. Studies of the following drugs, as well as their effect on the AUC of alprazolam, were carried out in vivo: ketoconazole increased the AUC of alprazolam by 3.98 times, itraconazole by 2.70 times; nefazodone - 1.98 times, fluvoxamine - 1.96 times and erythromycin - 1.61 times.
A really happy person in his entire life will never know the name of a single drug. Unfortunately, such people practically do not exist and sooner or later they all face the need to strengthen their bodies through pharmacological products. But it is better to find out before taking proksanaks what it is and in what dosages it should be applied.
Xanax: what it is, description, reviews, average price, instructions for use. Who is prescribed Xanax tablets?

Problems of the modern world
Life is permanent stress. Someone to him is more sensitive, someone less. But to deny this fact is meaningless, "behind every turn" we are waiting for another problem that can unbalance:
Emotional problems most often arise from a conflict of interest;
The more a person becomes obsessed with the situation, the more serious the consequences for mental health;
On the basis of nervous disorders, common problems can arise - with the skin, liver, or kidneys;
Simple suggestion or talk "heart to heart" is not enough, you need medical treatment.
In the West, this is taken more calmly, a visit to a psychotherapist is not something shameful, as is the use of prescribed medications. Every fifth teenager periodically visits such a doctor, in some countries this percentage is higher.
There is nothing wrong with acknowledging the fact that there is a serious mental problem. It’s not so scary to go to the roof, it’s much worse to do nothing about it and to remain in such a state for the rest of your life.
When is Xanax prescribed? Price
Thanks to the rapper "Pasha Technika", today millions of teenagers know about Xanax (alprazolam), in their understanding this drug will bring pleasure and will allow to get rid of problems.

Xanax tablets are not cheap. For a pack of 30 pieces of 2 mg will have to pay about 2000 rubles.
The rapper even started selling t-shirts with a print in the label of this tranquilizer. This is where the main problem lies - the popularization of surfactants will not bring to the good, the drugs from this group are shown to patients with mental disorders, and not to everyone who just wants to relax.

On the human body is a series of effects:

Sedative action - reduces the degree of irritability, causes drowsiness and emotional dulling;
Miorelaxing - removes muscle tension and cramps;
Nootropic - improves short-term memory.

Drink pills only if you have:
Prolonged depression;
Nervous states;
Panic attacks;
The state of alcohol withdrawal;
Suicidal thoughts
But whether to use this drug or not - only the doctor decides, tablets are dispensed with a prescription. He will come to conclusions about the expediency of the appointment after several visits and a detailed history taking.
How to take xanax?
Tranquilizer should be taken only for medicinal purposes. All other attempts to "indulge" with a potent agent can cost health, for good reason there are in the list of side effects:

Yellowness of the skin;
Unmotivated aggression;
Hallucinations;
Fainting;
Depression;
Allergic reactions.
 With addiction, things are even worse:

Increased sensitivity to light and sound;
Vomiting;
Cramps;
Panic attacks;
Tachycardia;
Sleep disturbance
If you are taking a drug solely to treat an existing disorder, your doctor will tell you the dosage you need.

It fluctuates and depends:

From the age of the patient;
From the condition of the patient;
From a specific pathology;
From the duration of the course of treatment.
There are two types of tablets - 0.25 and 0.5 mg each. Most often, the patient drinks 1 tablet 3 times a day, with meals. This is done to avoid complications of the gastrointestinal tract.
Accordingly, in different pathologies a person consumes from 0.75 to 1.5 mg per day, in severe cases, the upper bar can be increased to 4 mg.
The treatment is carried out in two stages - load and maintenance period. Duration can be up to eight months.
The doctor offers treatment with pills.
What effect does Xanax have?
Xanax refers to benzodiazepines. It is addictive, and withdrawal symptoms may be worse than the problems that were initially disturbed.

The drug is gradually discontinued, reducing the dosage weekly by one third. In conditions of uncontrolled admission, this practice becomes impossible.

The drug can really:

Relieve anxiety - due to sedation;
Affect memory and perception of reality - due to the impact on short-term memory;
To help look at problems from a different angle - by reducing emotional lability;
Relax due to muscle relaxant effects.
But you can get rid of problems, nervousness and stress with the help of completely different means that do not have a huge list of side effects.

Everyone chooses an "outlet" for himself:

Books;
Music;
Films;
Meditation;
Hiking in the mountains;
Travels;
Rest by the sea;
Consciousness-expanding substances.
You can also change your mind with the help of ordinary coffee. It affects the activity of the nervous system, but at the same time it is completely legal and practically harmless. In any case, can not be compared with tranquilizers for side effects.
An effective xanax tranquilizer?
Xanax (alprazolam) is a tranquilizer, sold in tablets of 0.25 and 0.5 mg and sold only by prescription. Due to its relative accessibility, he became popular among the “creative intelligentsia”, and then “went off to the masses”.

Psychotherapists prescribe it if patients have been identified:

Depression;
Panic attacks;
Anxiety-depressive states;
Neurosis;
Bouts of phobias;
Decreased activity.
The main problem is that Xanax is addictive. To get rid of it, you will have to show miracles of willpower, but those who started taking the drug uncontrollably, this is where the greatest difficulties arise.
To feel the whole range of side effects, in the form of strengthening the already existing problems, will have to everyone who brought the case to addiction.

The effectiveness of xanax is clinically proven, Western psychiatrists like to prescribe this drug for anxiety and depressive states in order to reduce the percentage of suicides among patients. And statistics show that treatment is effective.
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If a xanax appeared in the home first aid kit - what is it you already know. It only remains to make sure that all recommendations of the doctor will be followed.