24/7 Trolling!! ^.^

Mar 11, 2013 4:52 AM

#1001

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Mar 11, 2013 5:02 AM

#1002

ashjoben

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May 2012

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Every time i see that indian guy i rolfmao literally :D

Mar 14, 2013 4:32 PM

#1003

Lotus97

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Apr 2011

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Mar 20, 2013 12:37 PM

#1004

Lotus97

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Apr 2011

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Mar 22, 2013 5:30 PM

#1005

Lotus97

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The ‘folate trap’
The conversion of 5,10-methylen-THF into 5-methyl-THF, which is catalysed by MTHFR, is irreversible. The only way to make further use of 5-methyl-THF and to maintain the folate cycle consists in the vitamin-B12-dependent remethylation of homocysteine to methionine (regenerating THF). The methyl group transfer is therefore greatly dependent on 5-methyl-THF and the availability of vitamin-B12. In humans, this is the only known direct link of the metabolism of two vitamins; folic acid and vitamin-B12 both need each other.

In cases of vitamin-B12 deficiency, it is possible that, in spite of sufficient availability of folates (and 5-methyl-THF), an intracellular deficiency of biologically active THF arises. This situation is called a ‘folate trap’ (or methyl group trap) because, on the one hand, the concentration of 5-methyl-THF continues to rise but, on the other hand, due to it being prevented from releasing methyl groups, a ‘metabolic dead-end situation’ develops, which leads to the inevitable blockage of the methylation cycle. The co-factors for the C1-transfers decrease and replication as well as the cell division rate are reduced. Hence, the principal problem is the decreasing activity of methionine synthase under vitamin-B12 deficiency with secondary disorders affecting the folate metabolism and insufficient de-novo synthesis of purines and pyrimidines. The deficiency in active folic acids first affects the quickly dividing and highly proliferating haematopoiesis cells in the bone marrow and can even lead to pancytopenia.

Clinically, there is now no difference between vitamin-B12 deficiency anaemia and folic acid deficiency anaemia. If such an anaemia is treated with vitamin-B12, the blockage is immediately stopped and the blood count quickly normalises. However, if the anaemia is exclusively treated with folic acid, it is simply converted to dihydrofolate and THF.

Long-term therapy using high doses of folic acid could therefore conceal the real cause i.e. pernicious (vitamin B12-deficiency) anaemia for a long time. The serum folate continues to rise (congestion of non-regenerated 5-methyl-THF) while the intracellular folate concentration (erythrocytes) drops. This situation interrupts the methylation cycle with numerous cell processes, among them the synthesis of myelin, the nerve fibre lining, being blocked due to a deficiency of methyl groups. A long undetected (causal) vitamin-B12-deficiency can therefore result in serious neurological damage.
Exclusive folic acid therapy can lead to damage progression or even damage irreversibility.

Mar 23, 2013 9:42 AM

#1006

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I kind of get it, but this is probably how some people reacted:

removed-userMar 23, 2013 9:50 AM

Mar 23, 2013 2:33 PM

#1007

Lotus97

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Apr 2011

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@Wolfwood: Stephen Colbert and Jon Stewart in one post? DOUBLE KILL! I love the Doctor Who GIF. I know a few Who fans I'm sending it to.

And I don't really understand the Methyl Trap/Folate Trap myself. Due to my health I've had to research various things including methylation. I stumbled across those "It's a trap" meme pics and tried to figure out a clever way to post them. Any meme involving Star Wars is full of win. Cookies anyone?

Mar 25, 2013 9:13 PM

#1008

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Lol...

removed-userMar 25, 2013 9:58 PM

Mar 25, 2013 9:49 PM

#1009

Lotus97

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@wolfwood: That guy must have found a glitch in the Matrix because there's no other way that that's possible. I see you edited your post and added more. I was referring to the first GIF where the guy was jumping over all those people.

Lotus97Mar 25, 2013 9:56 PM

Mar 25, 2013 10:14 PM

#1010

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Yea, quickmeme is making my life difficult. I thought the same thing about the first gif, it's quite a "stretch". Awesome Matrix gifs, that movie is one of my all time favorites. Girls with jet black hair and blue eyes that look like the one up there are my all time favorites. I will now make it my mission to find more hot chick gifs. Here's the other two pics I wanted to put but quickmeme was being gay. xD

Admiral Akbar's thoughts on Taco Bell

Admiral Akbar's thoughts on 20+ Rhyming

Mar 30, 2013 3:17 AM

#1011

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Apr 1, 2013 11:46 AM

#1012

Lotus97

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Apr 2011

11910

@Wolfwood: haha, nice. I never knew that guy's name from Star Wars.

Apr 4, 2013 2:49 PM

#1013

Lotus97

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Apr 2011

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Lotus97 said:

I'd recommend watching the video I quoted before watching this next one

Apr 6, 2013 2:19 AM

#1014

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Apr 10, 2013 10:26 AM

#1015

Lotus97

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Apr 2011

11910

Haha, that was pretty good. RIP Whitney

Apr 12, 2013 12:20 PM

#1016

Lotus97

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Apr 2011

11910

This is a minor Bleach spoiler I guess. Not sure anyone who hasn't gotten that far will get what's going on, but I thought I warn people anyway.

Apr 12, 2013 8:36 PM

#1017

Lotus97

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Apr 2011

11910

GregRocks shared these with me

Apr 14, 2013 7:58 PM

#1018

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Apr 15, 2013 2:34 AM

#1019

furuabes

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Aug 2011

839

This is gross

Lotus97Apr 15, 2013 6:42 AM

Apr 15, 2013 5:14 AM

#1020

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Dude that's gross and funny, so many unanswered questions. xP

Apr 16, 2013 7:50 PM

#1021

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Apr 18, 2013 10:41 AM

#1022

Lotus97

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Apr 2011

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I've never had a cat or dog, but I still found that amusing.

Theme for this post is WTF Japan

Apr 23, 2013 8:50 AM

#1023

Lotus97

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Apr 2011

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Apr 23, 2013 8:06 PM

#1024

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Fools! This is the best song on you tube!

Apr 24, 2013 1:35 AM

#1025

Lost_Moon

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Oct 2011

1774

^ Creepy and gross....

^ Star Wars thing

Apr 24, 2013 10:10 AM

#1026

Lotus97

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Apr 2011

11910

Lost_Moon said:

^ Star Wars thing

Thanks, Mr. Obvious.

Apr 24, 2013 11:03 AM

#1027

Lost_Moon

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Oct 2011

1774

You never know who wont get it!

Apr 24, 2013 1:52 PM

#1028

Lotus97

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Apr 2011

11910

Luckily we both got the "Fools" reference which gives me an idea...

Apr 24, 2013 3:03 PM

#1029

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EDIT:(Fool! Some of your images didn't show!)

Fool! We need more excalibur images!

removed-userApr 24, 2013 3:06 PM

Apr 24, 2013 3:36 PM

#1030

ashjoben

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May 2012

13451

Fool, even your pics don't show :D

Apr 24, 2013 9:49 PM

#1031

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Hmmm, once I get going on yt, it's tough to stop. Need sleep. zzzz.

Apr 25, 2013 8:43 AM

#1032

Lotus97

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Apr 2011

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I have no idea who any of those characters are, but I do like Nightcore.

Apr 25, 2013 1:53 PM

#1033

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some of them are vocaloids, the robot girl is from
infinite stratos i think maybe, two samurais are from
sengoku basara, ranka and sheryl from macross frontier,
and the grey guy looks like snake maybe, and don't
know about the rest, the asain looking dude in the tower
and the guy with the antlers were the best

Apr 26, 2013 11:50 AM

#1034

Lotus97

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Apr 26, 2013 6:51 PM

#1035

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Apr 26, 2013 7:13 PM

#1036

Lotus97

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Apr 2011

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I don't really find them funny, but I liked the song.

Apr 26, 2013 11:29 PM

#1037

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The eternal question:

Apr 27, 2013 9:17 AM

#1038

Lotus97

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Apr 2011

11910

@one2the: Hey, haven't seen you in awhile

Apr 27, 2013 11:19 AM

#1039

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Lotus97 said:
@one2the: Hey, haven't seen you in awhile

Been studying in China for most of the past year-- where the internet is AWFUL.

Apr 27, 2013 11:31 AM

#1040

Lotus97

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Apr 2011

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one2the said:

Lotus97 said:
@one2the: Hey, haven't seen you in awhile

Been studying in China for most of the past year-- where the internet is AWFUL.

lol, how was China besides the crappy internet?

Apr 27, 2013 11:42 AM

#1041

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Lotus97 said:

one2the said:

Lotus97 said:
@one2the: Hey, haven't seen you in awhile

Been studying in China for most of the past year-- where the internet is AWFUL.

lol, how was China besides the crappy internet?

It was very enlightening -- I was able to do a bunch of travelling and studying (I was officially there to do research for my master's thesis), and the whole experience helped me figure out what I want to do for a career.

Apr 28, 2013 10:17 AM

#1042

Lotus97

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one2the said:

Lotus97 said:

one2the said:

Lotus97 said:
@one2the: Hey, haven't seen you in awhile

Been studying in China for most of the past year-- where the internet is AWFUL.

lol, how was China besides the crappy internet?

So what do you want to do as a career then?

Apr 28, 2013 11:51 AM

#1043

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Lotus97 said:

one2the said:

Lotus97 said:

one2the said:

Lotus97 said:
@one2the: Hey, haven't seen you in awhile

Been studying in China for most of the past year-- where the internet is AWFUL.

lol, how was China besides the crappy internet?

So what do you want to do as a career then?

Get a PhD in Education and work in either a government, a school district, or a university on developing curriculum and policy towards creating a more international and foreign student-friendly education system.

Apr 28, 2013 8:00 PM

#1044

Lost_Moon

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Oct 2011

1774

Apr 28, 2013 10:54 PM

#1045

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Lost_Moon said:

Pfft, what we really need is an Arnold-off:

Apr 29, 2013 7:41 PM

#1046

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Lmao, that video was funny as hell. xD

Apr 30, 2013 6:36 PM

#1047

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Apr 30, 2013 6:48 PM

#1048

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@Wolfwould

That was sexy.

May 1, 2013 11:51 AM

#1049

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May 1, 2013 5:45 PM

#1050

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Pewdiepie: Spongebob. Warning, animated violence and nudity.

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