Trinity Blood

Synopsis

Father Abel and Sister Noélle Bor are tasked with investigating the unexplained collapse of the National Palace in Barcelona, only to be told there that the collapse does not seem to be the result of foul-play. They use a break in the investigation to explore the city and enjoy the attractions that it offers; during the course of the day, a drunken Noélle tells Abel that she is in love with him, but he gently rejects her. When the investigation resumes later that evening, Noélle travels to a pharmaceutical company in search of more information; elsewhere, Abel finds the body of Professor Barrie. Isaak Fernand von Kämpfer appears and reveals to Abel the Silent Noise system that was developed by the professor and is capable of destroying entire cities in moments. He then activates the weapon and destroys much of Barcelona. In the devastation, Noélle is killed and, although Abel is able to destroy the system, Isaak escapes.

(Source: Wikipedia)