This will be a short review, because it's a short manga.
Nukoduke! starts off with the MC, Yuuya, finding two abandoned Nukos calling out for someone to take them. What is a Nuko, you ask? To put it simply, it's a species of cat that evolved to be more human-like.
Anyways, after a little bit of dialogue between them and some rain, Yuuya decides to take the two home with him.
The following chapters turn in to a slice-of-life comedy about Yuuya taking care of the Nukos, and the cute things the Nukos do. While the latter is typical in SoL comedies, the parts where Yuuya is taking care of the Nukos are pretty heartwarming. And there's quite a bit of them, so that's always good.
So, summarize an already short review, Nukoduke! is a nice, enjoyable little manga that will make you "D'aww" a lot. If you enjoy funny and/or adorable things, you should really give this a shot.