It is about 3 female best friends, that are so close to each other, that insulting, and being rude for a second to anyone of them, is actually quite normal for them. Because of it, and how relaxed the characters are to each other, their chemistry is flawless. You can easily connect it to some of your best friends where you push the jokes over the top, where insulting each other only brings fun... Talking about random stuff, and having fun with it. Additionally, there are a few side characters that add up. They have really unique personalities (good, bad or plain hilarious). With them, they fill up some episodes with a little bit different humor. They don't overuse any jokes, so every scene will be refreshing and funny. Since the characters are really fun, and can connect to real life, together with anime limits of graphical images that go beyond real world, it can show you humor never seen before.
When I mention those images, I'm referring to, first of all, the facial expressions that are unique to anime. That, of course, you can't replicate to filmed series. Or the movements that's possible to do in anime; like speed faster than light, or different body language unique to anime. That was animated and drawn pretty well, and that also increases the humor even more in Plastic nee-san. Those 2 elements together make a perfect comedy strictly unique to plastic nee-san, which makes this one of the best comedies ever. Further more, it is armed with a fitting soundtrack that goes on with the show pretty well.
I rarely feel sad, but when I do, I just go watch some Plastic nee-san. After a few minutes I'm as good as new. Because the interactions are so natural, and humor is really good, I would suggest this to anyone, even to those who never watched Anime before.
