 If you liked
Heppoko Jikken Animation Excel♥Saga
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 ...then you might like
Gintama
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Gintama is also full of reference type humour and is pure crack on crack on crack. It continuously makes fun of any and all anime titles so the more anime you watch the better it gets. I've been watching it over and over again ever since it started airing and I STILL haven't gotten sick of it, or failed to find new puns. Highly highly recommended!
While Excel Saga is shorter and came before Gintama, they both have a sense of randomness and parody in them. Gintama more so due to its no. of episodes. much hilarity ensues.
Comedy, parody, randomness and basically no plot. Both have crazy characters, silver-haired bishies and always hungry girls (Excel & Kagura) who have dogs. In both anime the main characters are in lack of money & need to pay the rent.
Both anime have aliens who invade Japan. :-D
Gintama is not as funny as Excel Saga but it still has some hilarious moments.
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Recommended by RenaPsychoKiller
The story and themes are quite different, but both shows parody other anime series. They're both a bit random, but very funny.
Both series has a strange sense of humor, break the four wall, good recap episodes and of course you can laugh a while.
Crazy comedy + parody
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Recommended by kuramarose