Blame!

Lain and Blame! are kindred spirits of the extremely trippy kind: machines blending with humanity, dialogues that throw the viewer off, a supra-reality of a cybernetic nature, intense imagery with distorted scenes and deliberate usages of static serve to create a very bizarre environment that takes the meaning of surreal to a whole different level. With this said, Lain is more consistent and offers enough to work on in terms of hermeneutics while Blame! is almost narrative free and extremely confusing.  

Ergo Proxy and Blame! are dark and unusual sci-fi titles. Both take place in a post apocalyptic scenario set in the future. A brooding atmosphere serves as the backdrop for the interaction between humans and thinking machines, exploring the thin line between them. Borderline supernatural creatures appear in both as well as living beings employed as powering devices. It should be taken into account, however, that Ergo Proxy is mostly a narrative driven anime that occasionally dips into speculations of a more philosophical kind while Blame! has hardly any plot to speak of and is one of the strangest experiences that any medium has to offer.  read more 

Both are dark sci-fi anime which take place in dystopian cities. Both have post-apocalyptic elements, brooding atmospheres and explore the relationships between humans and machines. Also, both have a strong main character who is skilled at weaponry and who usually battles against other machines. 

Pale Cocoon and Blame! are very mysterious, full of rampant technology, and quiet. They are also filled with lots of suspense about the world and the future of humanity, which will leave you on the edge of your seat begging for more. 

Both are frightening hard science fiction dystopias by the master of japanese sci-fi horror, Tsutomu Nihei. Incredible scenery, eerie silences and just as eerie music, uncanny looking characters and a wholehearted attempt to capture the setting and feel of Nihei's incredible manga. If you like one you'll also like the other. Blame! is sadly only a six part miniseries but Knights of Sidonia is the first full length anime of a Tsutomu Nihei project and it's already hitting the ground running with mecha action, grunge starships and transhumans trying to preserve the human race under the threat of horrific space monsters called Guanas. 

If you love Blame! manga and watched the new Blame! movie, but were disappointed by the changes they made to the plot, you should give the old ONA a shot... In case you haven't seen it yet! The ONA brings the original manga to life, which is always a delight to see, if you're a fan of the original, immense, brooding and mysterious world of Blame!. 

Both anime have a chaotic, disjointed plot, are set in a cyberpunk setting, and have both a similar main characters (a silent, black haired male and a mysterious female), with Ichise most likely taking some elements from Killy. Main difference is that Texhnolyze's plot starts to make more sense as the anime advances, while Blame remains confusing because the anime is a series of chapters randomly taken from the manga.