Tokimeki Tonight

same spirit 

Both family in the anime have supernatural power and the hero will love a Normal person...!! 

What Patalliro is to Scooby Doo, Tokimeki Tonight is to the Addams Family. - Both have same vibe, comedy and humour (though I think Patalliro is funnier) - Both of them are gag anime i.e. they both centre around physical slapstick humour and running gags. - Both have a vintage early 80s style of animation (though Patalliro's animation and art style is infinitely better and more stylish) - Both have a frivolous use of the supernatural, time-travel etc. without much care for the plot holes it creates (their focus is comedic) - Both are largely episodic but also have a running plot that overarches the series. - Both are full of similar shoujo tropes read more 

While Urusei Yatsura focuses less on the romance on the sidelines, they both have a similar goal of having a supernatural heroine try and win the affection of her love interest, while trying to keep away the competition and deal with their supernatural families too. They both have a similar vibe to them with the comedy as well. 

Similarities: Both about a vampire girl going to a human school and falling in love with a human boy while hiding monster powers. Differences: Karin has a blood lust to bite people due feelings of unhappiness while Renze bites objects and transforms into to them she also is a werewolf and has those powers as well. When it comes to romance Karin has a friendship with Usui and then feelings of love grow while Renze has a crush on Shun while he rejects her at first his feelings change. Tokimeki Tonight is a romantic slap stick comedy while Karin is a romantic comedy with some dramatic tones. read more 

Both are shoujo series about girls with the ability to transform into other people.  

Both have a supernatural female lead in it and some spooky aesthetics in it as well too.