 If you liked
Meteor Methuselah
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 ...then you might like
Saint Seiya: The Lost Canvas - Meiou Shinwa
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Very similar plot: Both are about 3 best friends (one girl and two boys) who lived together in a orphanage: the graceful girl, a boy who is energetic and funny and another one who was quiet. Eventually the quiet kind boy which is the reincarnation of an ancient god /spirit, betrays them all, kills everyone at the orphanage, wants to kill the girl too, but somehow wants the other boy to live and "chase" after him and his true goal is to destroy the world and kill all humanity so he can obtain true peace.