 If you liked
Blood+
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 ...then you might like
Koukyoushihen Eureka Seven
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Both animes have a character shrouded in mystery and both of them have another character who loves them whole heatedly in one way or another. The plot is surprisingly similar in many ways. However these similarities aren't felt until the end of the series. If i would compare these two, I'd say these two animes both contain the same plot while one took the dark and mysterious approach the other one took a more childish and lighthearted approach. At the end of the day, both contain the same deep meaning and may leave you with many hours to reflect on them.