Quick Thoughts:
Underwhelming.
Story:
Trigun is fairly episodic in the beginning. The main group of Vash, Meryl, Milly and, later on, Wolfwood visit a new city, Vash gets into comedic shenanigans, some kind of conflict occurs, they settle it and move onto a new city. This is the formula for about the first 10 episodes, after that each episodes delves bit by bit into Vash's past and internal conflict. I think it took a bit too long for the plot to get going, but the pacing was fine otherwise. I thought the ending was bit predictable, but it was fitting overall.
Art:
The art and animation shows its age, and the desert wasteland setting does it no favors; very boring color scheme. The character designs were fine; not bad but not memorable. The animation was generally decent, but it faltered during action scenes. There were a lot of still, panning shots.
Sound:
Outside of the guitar riffs in the mid-episode transitions, I don't remember much of the soundtrack. With the exception of Milly, whose voice I found annoyingly high-pitched, the voice acting was pretty good.
Characters:
There's a core group of 4 characters, but Vash is the only one who really sees any development. Milly and Meryl play comic relief much of the time, and Wolfwood proves to be a good foil to Vash in terms of their philosophies. The amount of depth they put into developing Vash made him a really compelling character, so I think it's fine that he gets most of attention story-wise. I found the antagonists however to be shallow in comparison. Their motives were questionable at best; they ended up seeming evil for the sake of being evil.
Enjoyment:
I think this is one of those anime where I would've appreciated it more had I watched it when it released, but now it just feels dated.