"How to become an Enabler 101" would be a better title.
The granny fox (she is not a loli by any standard) simply enables all the toxic behaviors Dead Eyes Guy (DEG or short) has and has a negative impact on his health overall.
Lets say its about alcoholism instead of overwork.
Granny keeps rewarding DEG behavior and no matter how drunk he gets home she takes all the blame and pampers him, she even uses the word "pamper".
DEG keeps getting drunker and drunker each episode and granny REMOVES all other responsibilites from DEG so he can drink in peace.
DEG health keeps getting worse and worse yet granny simply focuses on just enable him.
There is an entire week where DEG doesnt come home for being too drunk to even board the train and she just tell him to take a shower.
This is japan way to normalize overwork making stupid DEGs think its ok as long as they have a 2D waifu waiting at home.