Yotsuba reads like a heavily remixed version of Azumanga Daioh. Both are by Kiyohiko Azuma, and both should be prescribed remedies for the blues. Nothing on earth is a more potent cheerer-upper than Azuma's works =)))
Well, what's not similar? They are made by the same mangaka. They are both slice-of-life stories featuring young girls... doing strange, stupid, random, but funny things. And doesn't Chiyo-chan remind you of Yotsuba? (Facial wise... they have completely different... IQ points...)
Same author and same feel~ Both have cute characters and good laughs.
An obvious read for fans of the Azugirls. While Yotsuba doesn't have Osaka, it does have a nice flow and whatnot from not being in the 4-koma format. It also features the titular character of Yotsuba, who is slightly reminiscent of Chiyo, mixed with all the curiosity of a five year old.
They are both written by the same author, Kiyohiko Azuma, are slice-of-life style manga's, are mostly centered around female characters, and have no real deep plot to them, while still being an entertaining and adorable read.
Both of these series are written by Kiyohiko Azuma, though "Azumanga Daioh" is generally a yonkoma-style manga (four-panel) and "Yotsubato!"/"Yotsuba&!" is not. Both are slice of life, cute and generally innocent. They are comical and rarely ever get very serious or romantic, but the characters are memorable and fun. "Azumanga Daioh" has already ended and "Yotsubato!" is still being written.
both by the same creator, both extremely funny. Yotsuba is more kid friendly while Azumanga is more geared to teens and adults.
This is actually very simple. They are both similar, comedic and childish. They both are also from the same mangaka. Yotsuba& is maybe a little more childish than Azumanga Daioh. They are both very easy and quick to read. :3
While pretty much a given, Azumanga Daioh and Yotsuba to! encapsulate the fun in the mundane, brimming with innocence from writer Kiyohiko Azuma. If you love either of these series, then you'll definitely enjoy the other.